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FDA Mifepristone Review In The “Data Acquisition Phase"

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There is evidence that a significant percentage - about 10.9% - of women who abort using mifepristone experience medical side effects and injuries.  FDA published data on this politically tinged drug show much lower adverse effect levels.  U.S. Food and Drug Commissioner Marty Makary has promised a full and accurate review of this drug:

https://thefederalist.com/2025/12/10/fda-head-makary-commits-to-releasing-robust-abortion-pill-review-as-soon-as-it-is-completed/

FDA Head Makary Commits To Releasing ‘Robust’ Abortion Pill Review As Soon As It Is Completed
By Jordan Boyd - December 10, 2025

U.S. Food and Drug Commissioner Marty Makary confirmed on Wednesday that his agency’s review of the drug responsible for a majority of the nation’s abortions is underway and will be publicized as soon as results are finalized.

As stories of women suffering injuries and even death after taking abortion pills without medical supervision gained traction, U.S. Health and Human Services Secretary Robert F. Kennedy Jr. pledged that the administration would “study the safety of mifepristone.” By March 2025, Makary also promised “to review the ongoing data.”

News of the review, however, remained sparse and vague for most of 2025, prompting Congress and pro-life organizations to pressure the FDA to roll back Biden-era expansions that make it easier for people to obtain mifepristone via mail or a drug store pharmacy without a doctor visit or medical oversight. Polling suggesting a majority of likely voters also want the FDA to protect women from the dangers of abortion pills, also made an appearance shortly after both Kennedy and Makary announced the FDA “is conducting its own review of the evidence.”

The FDA previously failed to respond to The Federalist’s questions about who is leading the review, what process the review will follow, whether it had formally commenced, and how long it is estimated to take. In his December 9 sitdown with the Daily Signal, however, Makary confirmed that the FDA’s mifepristone review is in the “data acquisition phase” and will continue “under my auspices.”

“It’ll be reported up to me,” he said,.

While Makary did not specify the review’s timeline or end date, he committed to publicizing the FDA’s findings as soon as they “are available.”

“We’re not going to decide what the results are before we’ve done the study,” he continued. “We’re doing the study the right way. And when you do the study the right way, and I’ve done dozens of these studies as a Johns Hopkins professor, you gotta do the studies in data the right way with the right pace.”

The Ethics and Public Policy Center’s April 2025 examination of private medical insurance data determined that more than one in 10 women who take mifepristone suffer a serious adverse event. This determined rate of life-threatening complications, such as hemorrhage and infection, after pill-induced abortion is at least 22 times higher than what the FDA and mifepristone manufacturer Danco Laboratories boast.

The FDA’s study, Makary announced, is even “bigger” and “more robust” than EPPC’s undertaking. While the EPPC study was the “largest known study of the abortion pill” at the time, Makary said “it didn’t have granularity into the patient characteristics in a way that many researchers would want to have” which is why the FDA plans to probe mifepristone with an expanded review.

Makary’s comments come shortly after Bloomberg published an anonymously-sourced article claiming the FDA head was “Slow Walking a Long-Awaited Abortion Pill Safety Study.” Pro-life group SBA List Pro-Life America used the article to call for Makary’s firing.

No review is required for the FDA to reinstate some of the common-sense abortion pill safeguards. In fact, an embrace of requirements such as an in-person doctor visit would bring the second Trump administration’s FDA up to speed with the parameters that were present during the first Trump administration. Until that happens, it is easier now than ever for anyone to obtain mifepristone regardless of state laws prohibiting it.

The majority of abortions, 70 percent, are already believed to be unwanted, coerced, or inconsistent with the mother’s values and desires. A rise in abortion pill poisoning anecdotes further confirms that abusers and other bad actors take advantage of the FDA’s currently relaxed mail-order abortion drug provisions to force mifepristone on pregnant women.

The FDA recently added more mifepristone options to the market by approving a generic version of the abortion pill. The FDA claimed to The Federalist that the HHS secretary was required “by law” to “approve an application if it demonstrates that the generic drug is identical to the brand-name drug.” The off-brand abortion pill, however, went unapproved for 1,207 days under the Biden administration and 253 days under Trump before the FDA greenlit it.

Jordan Boyd is an award-winning staff writer at The Federalist and producer of “The Federalist Radio Hour.” Her work has also been featured in The Daily Wire, Fox News, and RealClearPolitics. Jordan graduated from Baylor University where she majored in political science and minored in journalism. Follow her on X @jordanboydtx.



   
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Abigail Nobel
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City wastewater treatment plants don't filter out mifepristone, so abortive mothers are probably not the only ones suffering side effects of this drug.

https://answersingenesis.org/sanctity-of-life/study-finds-abortion-drugs-in-us-drinking-water/

Study Finds Abortion Drugs in US Drinking Water

Ken Ham    |    August 4, 2026

Well, this is truly horrifying.

In 2025, 25 Republican lawmakers “signed a letter calling on the Trump administration to determine whether the abortion pill mifepristone has an environmental impact on the U.S. water system.”

Mifepristone is the first in a set of two drugs that end the life (are used to murder) of an unborn child, typically early in pregnancy (up to about 10 weeks gestational age). This drug is basically an antiprogestin, blocking the woman’s body from receiving the hormone progesterone that allows the uterine lining to accept the baby’s placenta. Unable to receive nourishment from mom due to the lack of progesterone, the baby dies and a second drug induces contractions to deliver the dead baby’s tiny body.

About 63% of abortions today are these chemical abortions (642,700 babies killed in 2023), and an increasing number take place at home. But what happens to the mifepristone after the woman takes it and kills her baby? The baby and the mifepristone leave the woman’s body and are flushed down the toilet to presumably be removed by the wastewater treatment plant—except no one was testing if conventional water treatment removed drugs like mifepristone from drinking water. Turns out, according to a new study, it doesn’t.

This study published in Issues in Law & Medicine found “a statistically significant amount of mifepristone was found in all but one of the nine water sources” that were tested (water came from Austin, TX; Blacksburg, VA; and Carbondale, IL). The study authors write:

"Conventional water treatment was not effective for removing this EDC [endocrine-disrupting compound] from water in all cities we tested. Two cities showed significant mean concentrations even in tap water."

What impact does this have on the health and fertility of the people drinking the water or the plants and animals that live in or around the water? No one knows because it’s never been studied! But the study summarizes what we do know about these kinds of compounds that disrupt the endocrine (hormone) system:

"Past research has shown that endocrine-disrupting compounds (EDCs), including steroid hormones, synthetic estrogens and progestins found in oral contraceptives, are present in water supplies. This problem remains an environmental and health concern, especially given the widespread use of contraceptives and the increased prevalence of medication abortion in recent years. These compounds have a number of deleterious effects on human and animal biology, particularly aquatic animals. Small amounts of these chemicals (parts per trillion) can affect the endocrine system of animals and humans. Progestins, including specifically the anti-progesterone synthetic steroid hormone mifepristone, have been found to have disruptive effects on the fertility and reproduction of fish. Moreover, further highlighting the potential for environmental toxicity and contamination, the FDA recommends treating any unused mifepristone pills as hazardous waste."

In other words, we don’t know the effect on human and environmental health yet for sure, but it’s probably not good!

According to an article reporting on this story:

“The EPA relied on studies that were done . . . in 1996 . . . to make sure that the excreted chemicals in the wastewater and the thrown away pills . . . would not reach a level that would hinder U.S. fertility rates,” [Vice chairman of the Committee on Health and Human Services in the Kansas House of Representatives Ron] Bryce said. “Since then . . . up to 63% or more of abortions are done by chemical abortions. Maybe—who knows—a million a year. And so the levels of mifepristone in our wastewater have grown dramatically.”

Infertility has skyrocketed . . . 84% between 1990 and 2021 globally. . . . The abortion pill was first approved in the U.S. in 2000 and approved in many European countries in the late 1980s and early ‘90s. In 2021, the study found that more than 110 million women faced infertility, and one in 10 women within the reproductive age range were infertile.

Bryce . . . is calling for a study to be done that analyzes infertility in light of mifepristone in the U.S. water system.

“[A] study that was done about a year ago on female frogs [found that] when they were exposed to mifepristone that is considered the level that is in our drinking water today, they had half as many babies,” he said. “And so we’re looking at fertility rates that are very low in the United States and in the Western civilization. . . . It’s either environmental factors or it’s behavioral factors. It’s probably a combination of the two. . . . We really need to get to the bottom of the environmental factors that might be contributing to this, and it’s just obvious that we need to look at the levels of mifepristone in our water.” [emphasis added]

Abortion harms everyone, babies first and foremost, but also men and women—even those not involved in any way with abortion.
Abortion advocates love to say that what a woman does with “her body” (but really, we’re talking about a woman’s body and a totally separate body, her unborn child, which is not part of her body but has his or her own DNA—a unique combination of information different to any other human being) is a medical decision between her and her doctor. But abortion doesn’t just impact a woman and her baby, who loses his or her life. This new study highlights yet another way abortion impacts everyone as millions of un-consenting Americans ingest harmful compounds that may wreak havoc on their own endocrine system and their future fertility (not to mention the environmental considerations that also impact everyone in one way or another!).

Abortion harms everyone, babies first and foremost, but also men and women—even those not involved in any way with abortion. This new study is just another example of the consequences of a culture that has abandoned God’s Word as the foundation for morality and has legalized and commercialized the slaughter of the unborn.

Oh, and it’s a good reminder to filter your tap water! The study suggests, “Maximum removal requires tertiary treatment, such as membrane bioreactors [like a reverse osmosis system], oxidation, or ozonation.”

Thanks for stopping by and thanks for praying,
Ken



   
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